… Another ubiquitin E3 ligase linking protein homeostasis and ageing is the quality control …
inates DAF-16, the worm FOXO, counteracting polyubiquitination by RLE-1 E3 ligase and its sub…

… remove ubiquitin conjugates (deubiquitylases), regulate the … to E3-ligases, catalyzing covalent
attachment of ubiquitin to … factor DAF-16 with the RING-finger E3-ubiquitin ligase RLE-1 […

… elegans, the null mutation of the RLE-1 E3 ubiquitin ligase … -16A-regulated genes is required
to elicit daf-2-induced daf-16-… muscle and intestinal DAF-16 combat reproductive aging 67 . …

… DAF-16 is SUMOylated, and that this modification represses the transcriptional activity of
DAF-16… that activation of SKN-1 negatively regulates DAF-16, which is in agreement with our …

… The ubiquitin proteasome system (UPS) also regulates DAF-16 activity. The loss of rle-1, a
gene encoding an E3 ubiquitin ligase, increases lifespan, 29 whereas the loss of math-33, a …

… the size and topology of polyubiquitin chains, thereby affecting … , catalyzes the ubiquitin-mediated
degradation of DAF-16/… the role of RLE-1, promoting longevity via DAF-16 stability in …

… factor, DAF-16, that governs most of … elegans, the RLE-1 ubiquitin ligase controls dauer
arrest and life span by promoting the polyubiquitination and proteasomal degradation of DAF-16…

… The RLE-1 E3 ubiquitin ligase is important to keep DAF-16 on … E1 catalyzes ATP and uses
this energy to activate the ubiquitin … to polyubiquitinate DAF-16 and target it for proteasomal …

… E3 ubiquitin ligase binds both the E2 enzyme and the target substrate to catalyze the transfer
of the activated ubiquitin to … elegans revealed that RLE-1 colocalized with DAF-16, while in …

… in polyubiquitin signals with distinct topologies (Figure 1). The post-translational modification
of … Finally, the ubiquitin-loaded E2 teams up with an E3 ubiquitin ligase to conjugate the …